Platelet Factor 4

A CXC chemokine that is found in the alpha granules of PLATELETS. The protein has a molecular size of 7800 kDa and can occur as a monomer, a dimer or a tetramer depending upon its concentration in solution. Platelet factor 4 has a high affinity for HEPARIN and is often found complexed with GLYCOPROTEINS such as PROTEIN C.

Also Known As:

Heparin Neutralizing Protein; PF4 (Platelet Factor 4); gamma-Thromboglobulin; CXCL4, Chemokine; Chemokine, CXCL4; gamma Thromboglobulin; Antiheparin Factor; CXCL4 Chemokine; Chemokine CXCL4; Blood platelet factor 4

Pharmalogical Action Categories:

Coagulants

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Intercellular Signaling Peptides and Proteins: 29768
    - Cytokines: 164289
      - Chemokines: 24660
        CXC Chemokines: 2031
        Platelet Factor 4: 1062
  - Blood Proteins: 12459
    - Blood Coagulation Factors: 5376
      - Platelet Factor 4: 1062
- Peptides: 82426
  - Intercellular Signaling Peptides and Proteins: 29768
    - Cytokines: 164289
      - Chemokines: 24660
        CXC Chemokines: 2031
        Platelet Factor 4: 1062
Biological Factors: 2472
- Intercellular Signaling Peptides and Proteins: 29768
  - Cytokines: 164289
    - Chemokines: 24660
      - CXC Chemokines: 2031
        Platelet Factor 4: 1062
- Blood Coagulation Factors: 5376
  - Platelet Factor 4: 1062
- Chemotactic Factors: 3762
  - Chemokines: 24660
    - CXC Chemokines: 2031
      - Platelet Factor 4: 1062
- Inflammation Mediators: 1113
  - Chemokines: 24660
    - CXC Chemokines: 2031
      - Platelet Factor 4: 1062

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Disease

Drug/Important Bio-Agent (IBA)